Event Date
Neil Johnson, Professor, Fox Chase Cancer Center, presents "BRCA1-PALB2 protein complexes in DNA repair and cancer".
My laboratory studies mechanisms of DNA damage detection, repair, and signaling that occur in homologous recombination (HR) gene mutation-containing organisms and cancers. We use a range of approaches, including cell biology, mouse genetics, and therapy resistance modeling, to understand basic biological processes and their implications for tumorigenesis and chemotherapy sensitivity. I have made multiple contributions toward understanding mechanisms by which BRCA1 mutation-containing alleles generate protein products that promote HR repair and chemotherapy resistance. Recently, we have generated several new Brca1 mutant alleles to dissect the impact of loss of various BRCA1 functional domains on DNA repair pathway choice and mouse development. Furthermore, we have generated several Brca1 and Palb2 coiled-coil domain mutated mouse models to study how this protein complex regulates RAD51 recruitment to DNA damage sites as well as post-DNA end resection repair events.
Host: Wolf Heyer (wdheyer@ucdavis.edu)
Also available via Zoom
Meeting ID: 975 1692 7543, Passcode: 423147