Position Title
Associate Professor
Position Title
Associate Professor
- Molecular and Cellular Biology
4B Briggs Hall
Bio
Research Interests
As a researcher, my work focuses on the structural biochemistry, enzymology, regulation, and cellular biology of protein-nucleic acid interactions. Utilizing biochemical and structural methods, I study protein/nucleic acids structure and function with a particular emphasis on enzymology and molecular recognition. My model systems include nucleotide-biosynthetic enzymes, with specific research targets on the mechanism and regulation of E. coli Cytidine Triphosphate (CTP) Synthetase and the regulation and dynamic localization of human CTP synthetases.
Graduate Program Affiliations
Education and Degree(s)
- 1982 B.A. in Chemistry, State University of New York, Purchase
- 1989 Ph.D. in Chemistry, University of California, Berkeley
- 1997 Post-doctoral X-ray Crystallography IMB, University of Oregon
Publications
- Lynch EM, Hicks DR, Shepherd M, Endrizzi JA, Maker A, Hansen JM, Barry RM, Gitai Z, Baldwin EP, Kollman JM. (2017) Human CTP synthase filament structure reveals the active enzyme conformation. Nature structural & molecular biology 24(6):507-514.
- Habrian, C, Chandrasekhara, A, Shahrvini, B, Hua, BH, Lee, J, Jessinghaus, R, Barry, R, Gitai, Z, Kollman, J, and Baldwin, EP. 2016. Inhibition of E. coli CTP synthetase by NADH and other nicotinamides, and their mutual interactions with CTP and GTP. Biochemistry 55, 5554-65.
- Barry RM, Bitbol A-F, Lorestani A, Charles EJ, Habrian CH, Hansen JM, Li H-J, Baldwin EP, Wingreen NS, Kollman JM, and Gitai Z. 2014. Large-scale filament formation inhibits the activity of CTP synthetase. eLIFE 3, e03638.
- Ozes, A, Feoktistova, K, Avanzino, B, Baldwin, E and Fraser C. 2014. Real-time fluorescence assays to monitor duplex unwinding and ATPase activities of helicase proteins. Nature Protocols 9, 1645-61.
- Meckler JF, Bhakta MS, Kim M-S, Ovadia R, Habrian CH, Zykovich A, Yu A, Lockwood SH, Morbitzer R, Elsäesser J, Lahaye T, Segal DJ, and Baldwin EP. 2013. Quantitative Analysis of TALE-DNA Interactions Suggests Polarity Effects. Nucleic Acids Res. 41, 4118-28.