Position Title
Professor
Position Title
Professor
- Molecular and Cellular Biology
204 Briggs Hall
Bio
Research Summary
My research focuses on the molecular mechanisms of protein synthesis and RNA biology, aiming to understand the fundamental processes of cellular and viral gene expression and regulation. I delve into the intricate details of how ribosomes, the molecular machines responsible for protein synthesis, are regulated and how various factors influence their function. Through biochemical and structural approaches, I explore how messenger RNA is selected for translation into protein, seeking to uncover new insights into the control of gene expression. My research has significant implications for understanding diseases caused by errors in protein synthesis and RNA regulation.
Graduate Program Affiliations
Education and Degree(s)
- 1995 B.S. in Biology, University of Sussex
- 1999 Ph.D. in Biochemistry, University of Sussex
Publications
- Querido, J. B., Sokabe, M., Kraatz, S., Gordiyenko, Y., Skehel, J. M., Fraser, C. S., and Ramakrishnan, V. Structure of a human 48S translational initiation complex. Science. 2020 Sep 4;369(6508):1220-1227.
- Sokabe, M, and Fraser, C. S. Toward a Kinetic Understanding of Eukaryotic Translation. Cold Spring Harb. Perspect. Biol. 2019 Feb 1;11(2).
- Avanzino, B. C., Fuchs, G., and Fraser, C. S. Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9611-9616.
- Sokabe, M., and Fraser, C. S. ATP-dependent restructuring of the 40S subunit decoding site during mRNA recruitment. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6304-6309.
- García-García, C., Frieda, K. L., Feoktistova, K., Fraser, C. S., and Block, S. M. Factor-Dependent Processivity in the Human eIF4A DEAD-box Helicase. Science. 2015 Jun 26;348(6242):1486-8.