Molecular & Cellular Biology

Worms Reveal Just How Cramped Cells Really Are

In a new study published in Science Advances on September 10, a team of UC Davis researchers tracked the movement of fluorescent particles inside the cells of microscopic worms, providing unprecedented insights into cellular crowding in a multicellular animal. They found that the cytoplasm inside the worms was significantly more crowded and compartmentalized than in single-celled yeast or mammalian tissue culture cells, which are more commonly used to gauge internal cellular dynamics.

This Snail’s Eyes Grow Back: Could They Help Humans do the Same?

Human eyes are complex and irreparable, yet they are structurally like those of the freshwater apple snail, which can completely regenerate its eyes. Alice Accorsi, assistant professor of molecular and cellular biology at the University of California, Davis, studies how these snails regrow their eyes — with the goal of eventually helping to restore vision in people with eye injuries.

CBS Dept. and Grad Group Faculty Elected as AAAS Fellows

Three faculty affiliated with the College of Biological Sciences are among the eight UC Davis faculty newly elected as fellows of the American Association for the Advancement of Science, announced March 27. They are: Frédéric Chédin, a professor and chair in the Department of Molecular and Cellular Biology; Dario Cantù, a professor in the Department of Viticulture and Enology; and Huaijun Zhou, a professor in the Department of Animal Science.

Among the Academies: When Plants Step Out of the Shadows

A flowering plant might not be able to tell how many fingers you’re holding up, but it can tell whether it’s light or dark outside and might grow differently if it suddenly finds itself in the shade of another plant.

Plants do that through photoreceptors, which are a major focus of research for John Clark Lagarias, a distinguished professor emeritus of molecular and cellular biology.

Photoreceptors have important uses, like measuring the length of the day; plants can tell when seasons change because the days get longer or shorter.

Student-Led Research Reveals “Off-Switch” for Autophagy

A chance observation in an undergraduate laboratory class has shed light on a key cleaning and recycling process carried out by all eukaryotic cells. Autophagy breaks down organelles, proteins and other molecules so their components can be reused and plays a protective role in preventing disease. However, when autophagy doesn’t work correctly, it’s associated with cancer and neurodegenerative diseases including Alzheimer’s. Previous research has uncovered how cells activate autophagy, but little is known about how it is switched off.